Research conclusions:(1)In the Qaidam lake deposited basin，the salt is continuously carried and deposited in this relatively closed basin，wind and water as the medium. (2)The salt lake located in the footslope of the Qilian Mountains and the Kunlun Mountains is amply supplied with water, the soft clay，seasonally frozen soil and karst are widely distributed and difficult to be disposed，the route is chose to pass around. (3)In the region of Yadang landform，the land is covered by the “salt bed”，some part is desertificated，the bridge-plan is chosen to pass through the sand belt in short distance. (4)In the dry early lake sedimentary basin，the geological conditions are relatively good for the route passing though in long distance. (5)In engineering construction，the sand should be controlled by salt，the “salt bed" should be protected，the water environment should be controlled in stability. (6)The research results provide a certain reference value for line selection and engineering design of the similar geological characteristics.