Research conclusions: This paper analyzs the the main geological problem for Yunnan-Guizhou area on Shanghai- Kunming PDL, puts forward the corresponding countermeasures for geological location research :( 1) For major adverse geological problems，should be mainly around the avoidance.(2)For the geological problems unable to avoid，should take the principle of avoid the important and dwell on the trivial to reduce engineering risk.(3)For the concealed engineering geological problems hard to find out，should take the form of project risk control to ensure project safety. (4)This paper provided reference to the geological location with similar geological conditions.