Abstract:Basis on characteristics of Qinghai-Tibet plateau and railway and highway entering into Tibet, six theoretical principles on selection route of traffic main-line entering into Tibet for mitigating mountain hazards as follows. l)Rotre perpendiculars to mountain chain and vertically climbs up the No. 3 relief step with tall bridge and long tunnel. 2)With circle and turn respectively, route separates oneself from river valley and climbs up the plateau surface as soon as possible. 3)It is main for mitigating hazards of route along river that avoiding mountain hazard gruop with adopting bridge of stride across the river and tunnel of entering into hill. 4)Because mountain hazards have difference related to aspect of valley ,most route along river must through schattenseite and the route of through another side must be a few. 5)In serious hazard and group hazard sections ,route along river would rather more high and must not more low. Elevation of the route must over largest level of the hazards. 6)On the plateau surface, most road must be filled and cut road must be a few. The route is determined by best high of filling.