Abstract:This paper gives an introduction to the construction technique and precautions for large-span prestressed concrete continuous box girder in soft foundation area during construction of Dongxihu Interchange Crossing Bridge, proposes the construction programme with supporting all round and casting for one time for continuous box girder at small radius line, which resolved the problems related to the soft foundation, ensured compactness inside, beauty outside and round line of box girder, and saved the cost, analyzes the quality control and monitoring of ground treatment, supporting laving, temlate installation, concrete casting and stress system setting up, which provides good experience to such construction.