Research conclusions :(1) The three faults of Chengdu to Kangding of Sichuan - Tibet Railway where the strong earthquake occurred，have fault activity and have a greater influence on the railway line selection， to reduce risk by reasonable line selection. (2) The project effect caused by active faults has engineering damage caused by The surface rupture，vibration damage caused by seismic waves，increased difficulties of engineering construction or engineering plan not workable caused by geothermal anomaly in fracture controlled area，the secondary disasters such as landslide，debris flow，collapse damage to engineering formed because of faulting. (3)The geological route selection in active faults area should give full consideration to the activities of the active faults and the main engineering problems caused by it. (4) The research results are mainly applied to the geological route selection work of Chengdu to Kangding in Sichuan - Tibet railway.