Research conclusions：Design and construction of New Guangzhou Railway Station involved many specialized subjects. The code for railway bridge was adopted to the bridge design and the code for building construction was adopted to the waiting hall on the top and canopy. As the bridge and the upper building jointly bore the load and deform coordinately, it was necessary to do calculation for them as a whole. As the structure was good at bearing load as a whole, the whole building had a good earthquake-resistant capacity and dynamic capacity. As the nodes of New Guangzhou Railway Station were very complex, the adequate measures were taken for the partial structure. In addition, as the construction of bridge, waiting hall, canopy and subway were conducted across, a reasonable construction plan was needed.