Research conclusions:(1)Yuxi to Mohan railway landform undulates terribly，geological conditions are complicated， risk is higher. With the comprehensive comparison of lots of schemes，make the route through the hot springs low temperature zone，the influence of active faults is small，tunnel risk is reduced greatly，and a solid foundation for the future design is laid. (2)Different railway projects has the different risk of route design. According to the principle of route design that risk should be analyzed，from the analysis of the design process，the comprehensive route design on geology and risk in pre-feasibility phases is dominated by macro analysis，the route selection principle of significant risk should be dominated by regional geological data and site reconnaissance situation，thus instruct route selection design. Based on further investigation on the geological conditions，the major geological risk should be verified in feasibility phases，the geological special research is carried out when necessary，engineering measures should be implemented in the preliminary design and construction drawing phases.(3)This research has a certain reference significance for other high-risk railway projects.