Abstract:The paper expounds the causes of formation of the desert ,the characteristics of the motion of sand blown by the wind and its mechanism,as well as the subgrade defects which may be affected by sand blown by the wind during construction of railway in the desert regions. Therefore,during route selection of railway line,the change of wind direction and the law of its motion should be taken into at- tendon,and the regions in which sand dunes may be easily formed and the serious quicksand regions should be avoided and taken a devious route. In accordance with the practical example of the route selection of the Shen-Yu Railway,the design feature of railway in the desert regions is introduced in detail in this paper.