Research purposes ： Vibration and noise issues caused by high - speed railway have received extensive attention，the application of slab track with anti - vibration structure would be an effective measure to deal with this problem. A study on the harmonic response of CRTS Ⅱ prefabricated slab track with anti - vibration structure was conducted by establishing a 2 - D slab track model in frequency domain. Based on vibration theory and finite element method，transmit function ( receptance) and vibration isolation efficiency were taken as two evaluation index in order to research the vibration transmission and vibration isolation performance. From numerical simulation of the impact of the basic slab track parameters on the vibration isolation efficiency，some recommended slab track parameters were put forward. Research conclusions:(1) CRTS Ⅱ prefabricated slab track with anti - vibration structure has great vibration isolation effect in mid and high frequency area. (2 ) Increasing the thickness and density of the track slab can improve the vibration isolation efficiency of the track system，and the slab with higher density is more effective. (3) The suggested damping range of the anti - vibration pad is 0. 1 MN ? s/m3 ~ 0. 25 MN ? s/m3，and in the allowable range， a lower surface rigidity is preferable. (4) The research results can provide a theoretical reference for the design and construction of CRTS Ⅱ prefabricated slab track with anti - vibration structure.