Abstract：Research purposes： In the process of urbanization, the expansion trend of big cities brings many problems such as traffic congestion and environmental pollution. In order to guide the expansion type of the city from single center to multiple center, and achieve the sustainable development, the paper researches on the urban rail transit design between sub-center and center of city.  Research conclusions： (1)When designing the urban rail transit between sub-center and center of city, should strengthen the rail transit line planning between sub-center and center of city, give priority to use the quality routing resources, determine the urban rail network scale based on the passenger flow, determine whether need to lay out the express line according to the urban planning requirements. (2)For the urban rail transit between CBD and Sub-CBD, the subway system and the underground line is generally suitable. However, for the urban rail transit between sub-center and center of city, the general requirements are higher speed target value and larger station spacing, the laying mode is the ground line or elevated line, and should take full account of the TOD development strategy.（3）The research conclusion will provide theoretical guidance for the urban rail transit design between sub-center and center of city. 