Abstract：Research purposes： In the construction of high-speed railway, there are no mature experiences for reference about subgrade technical problems, such as subgrade packing filling, subgrade side slope protection in the wind area, foundation treatment of Gobi soil, and sand control engineering in the passenger dedicated line from Lanzhou to Xinjiang. Through experimental research, the problems of railway subgrade are solved in the construction project, and the technical support is provided for the smooth construction of the passenger dedicated line from Lanzhou to Xinjiang.  Research conclusions： (1) Through experimental research, the standard of subgrade filling and the influence factors of compaction quality, foundation treatment of Gobi soil, the adaptability and the protection effect of different subgrade slope protection measures are put forward. (2)Through the analysis of the main form of sand flow, characteristics of wind sand flow along the railway line in Gobi area, sand control measures for constructing high speed railway in strong sandstorm area of Gobi are put forward.(3)The reasonable values of the parameters such as the reasonable form, location, height, wind load and the force of the subgrade are put forward, while the experimental parameters for train safety evaluation, train and windbreak structure, surface pressure wave propagation are provided. (4) The research results are applied to the design and construction of the passenger dedicated line from Lanzhou to Xinjiang, which provides a reference for similar projects. 