Abstract：Research purposes： Structural safety and stability of high rock temperature tunnel in meizoseismal area is one of the hot issues that need to be studied and solved urgently. In order to reduce the service temperature of the support structure of high rock temperature tunnel and improve its safety at the time of earthquake, taking Jiwoxiga tunnel on Lasa-Shigatse railway as the research background, this paper studies the heat resistant and anti-seismic technology of high rock temperature tunnel in meizoseismal area by using finite difference numerical simulation technique.  Research conclusions：（1）It proves that he best heat resistance scheme of tunnel rock grouting, that is, the grouting thickness is 3 m, the grouting area and the initial branch spacing are 0 m contact grouting.（2）It proves that the tunnel is the best anti-seismic scheme for the use of surrounding rock grouting, that is, the grouting thickness is 3 m, the 〖JP2〗 interval between the grouting area and the initial branch is 0.5 m.（3）Considering the heat-resisting effect and the anti-seismic effect of the supporting structure, the high-temperature tunnel in meizoseismal area is recommended to use the best anti-seismic scheme of surrounding rock grouting to design it.（4）The research results can provide reference for the development of the heat resistant and anti-seismic technology of high rock temperature tunnel in meizoseismal area. 