Abstract：Research purposes： Creep camber is likely to appear in the prestressed bridges of high-speed railway which is very sensitive to track irregularity. It is a serious problem in engineering to study the influence of irregularities caused by creep camber of prestressed bridge on the train-longitudinal connected slab track-bridge coupling dynamic system. Based on vehicle-track coupling dynamic theory, a three-dimensional finite element coupling dynamic model of high speed train-longitudinal connected slab track-bridge, which considered the nonlinear contact among different components of slab track-bridge system, was established and verified. Using the established dynamic model and taking high-speed train passing longitudinal connected slab track on bridge with creep camber, the dynamic characteristics of the coupling system were studied.  Research conclusions： (1) The creep camber of bridge has a great influence on the vibration acceleration of train, however, the influence on the vibration acceleration of bridge is not obvious. (2) The creep camber of bridge has some influence on maximum wheel-rail force, positive bending moment of rail, tension force of fastener, tensile stress of track slab and base plate, pressure stress of CA mortar, but the influences for them are different. It has relatively small influence on maximum wheel-rail force, but large influence on maximum positive bending moment of rail, tension force of fasteners, tensile stress of track slab and base plate, pressure stress of CA mortar. (3) The local void among the slab track-bridge system caused by creep camber of bridge has a great influence on the dynamic stress characteristics of high speed train-longitudinal connected slab track-bridge coupling system. (4) The research results will provide theoretical basis to control the value of creep camber of prestressed bridge of high-speed railway with longitudinal  connected slab track on it. 